New natural prokinetic formula to solve functional dyspepsia
Introducing Dispepril®: new and effective natural prokinetic formula that combines 300 mg of ginger root extract with 150 mg of bifractionated extract of perilla leaves (Perilla frutescens) showing a marked anti-dyspeptic activity both in gastric and intestinal sites.
Functional Dyspepsia and what it’s all about
According to Mayo Clinic Functional dyspepsia (FD) is a term for recurring symptoms of an upset stomach that have no obvious cause. A constant condition whose symptoms resemble those of an ulcer, including pain or discomfort in the upper abdomen, bloating, belching and nausea.
FD is really common in Western societies, moreover it has an important impact on the quality of life of the patients who are, therefore, continuously seeking for ways to improve their condition.
Since FD has a multifactorial etiopathogenesis, its treatment depends on its symptoms and may involve different medications that at times are used in combination with each other, such as proton pump inhibitors, prokinetics, anti-emetics, spasmolytics, anxiolytics or antidepressants.
However, the risk/benefit ratio of the use of drugs sometimes is so high as to give rise to the need for alternative treatments.
The phytotherapeutic alternatives are essentially based on the use of ginger root extract (Zingiber officinale), which has always been used in the treatment of some purely gastric disorders of dyspepsia, such as nausea, vomiting and gastric dysmotility, but which would need to be associated with other extracts to counteract both gastric symptoms and other symptoms associated to the functioning of duodenum muscles.
Dispepril®: a natural prokinetic formula offering a 360-degree solution to people with FD
In this line of ideas PharmExtracta developed Dispepril® a new and effective natural prokinetic formula that combines 300 mg of ginger root extract with 150 mg of bifractionated extract of perilla leaves (Perilla frutescens), that has a marked anti-dyspeptic activity both in gastric and intestinal sites.
The ginger extract of Dispepril® deserves itself a thumb up since it is standardized to contain 10% gingerols and shogaols, which is a remarkable concentration.
But what really sets Dispepril® apart from other products is the presence of the bi-fractionated extract from perilla leaves obtained with a patented extraction method that makes it possible to preserve both the hydrophilic and the lipophilic active components including the hydrophilic vicenin-2, endowed with prokinetic, antispasmodic, and anti-inflammatory effects, and the lipophilic terpenoid perilla ketone that improves the functioning of duodenum muscles. These components not only have an action in the gastric site but also propel the peristaltic wave in the small intestine.
Dispepril® can have a complete action to solve the symptoms of functional dyspepsia, unlike other phytotherapeutic products or drugs that typically fail to treat this kind of problem because they do not take into consideration the “gut aspect” of it.
Clinically proven effectiveness of Dispepril® against FD symptoms
The 2019 study Effectiveness of a nutraceutical supplement containing highly standardized perilla and ginger extracts in patients with functional dyspepsia reports the results of the evaluation of the clinical activity of Dispepril® that was tested on 58 patients diagnosed with functional dyspepsia.
The patients under evaluation had received their diagnosis of FD on average 2.2±2.8 years earlier and 21 out of 58 patients previously took medication or self-medication for FD in the past.
The study treatment consisted of Dispepril® 1 tablet 30 minutes before lunch and 1 tablet 30 minutes before dinner for 14 days.
The symptoms were assessed according to a score from 0 to 7 to be attributed to seven specific gastrointestinal symptoms (epigastric pain, heartburn, gastric reflux, nausea, borborygmi, early satiety and diarrhea/constipation) evaluated at enrolment and 7 days after the end of treatment.
After 14 days of therapy the symptomatology was reduced overall by more than 70% on average; tolerability was 8.3/10 and adherence was over 95%.
The use of Dispepril® has therefore proved to be very effective and safe in the treatment of the most common symptoms of functional dyspepsia, satisfying the needs of patients and doctors who, when suitable, prefer phytotherapeutic treatments rather than pharmacological treatment, especially when the risk/benefit ratio of the drugs it is too high.
